What helps with Cymbalta withdrawal symptoms

What helps with Cymbalta withdrawal symptoms- DATOS
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Cymbalta, also known as duloxetine, is a useful medication for treating conditions like depression, major depressive disorder, anxiety disorder, and chronic pain. However, when you decide to stop using Cymbalta or any antidepressant, you might face withdrawal symptoms.

Research indicates that approximately 44% of individuals who stop taking antidepressants like Cymbalta may encounter withdrawal symptoms or something called antidepressant discontinuation syndrome. It is essential to be aware of the signs of Cymbalta withdrawal and this discontinuation syndrome, as well as how to manage them safely when discontinuing this medication. Continue reading to find out more.

Why Cymbalta Is Prescribed

Doctors prescribe Cymbalta, which is a type of medication known as a serotonin and norepinephrine reuptake inhibitor (SNRI), for various purposes in different age groups:

  • It is used in adults to treat depression, which is also known as major depressive disorder.
  • It can help manage anxiety in both adults and children aged 7 and older who have generalized anxiety disorder.
  • Cymbalta is prescribed to adults dealing with nerve pain caused by diabetes, a condition known as diabetic peripheral neuropathic pain.
  • It is also used to alleviate fibromyalgia pain in adults and in children aged 13 and older.
  • Additionally, it can be prescribed for chronic muscle pain in adults.

Other medications and brands within the same class of drugs, known as serotonin-norepinephrine reuptake inhibitors (SNRIs), include desvenlafaxine (Pristiq), duloxetine (Cymbalta, Drizalma Sprinkle, Irenka), levomilnacipran (Fetzima), milnacipran (Savella), and venlafaxine (Effexor, Effexor XR).

Is It Safe to Quit Cymbalta?

Ending your use of any medication, like Cymbalta, without a gradual reduction can be risky. Your body gets used to having a certain level of the medication, and stopping it suddenly might lead to strong withdrawal symptoms, a condition known as antidepressant discontinuation syndrome, or other health problems.

Before you decide to stop taking Cymbalta all at once, it is essential to talk to your doctor to make sure you can do it safely.

Cymbalta Withdrawal Signs

When you stop taking Cymbalta, you might experience various symptoms, such as:

  • Feeling dizzy
  • Experiencing brain zaps
  • Feeling nauseous or throwing up
  • Dry mouth
  • Having headaches
  • Feeling tired
  • Trouble sleeping
  • Reduced appetite
  • Restlessness
  • Low blood pressure
  • Being easily irritated or emotional
  • Diarrhea
  • Constipation
  • Cold or flu-like symptoms, like shivering or sweating.

Cymbalta is a medication that affects both serotonin and norepinephrine systems in the body. Quitting it suddenly can lead to these unpleasant symptoms.

How Can I Reduce Withdrawal Symptoms

Make sure to have a conversation with your doctor before discontinuing Cymbalta.

In addition to gradually tapering off the medication, you and your doctor might decide to switch to another treatment option. There are many choices available for managing depression, anxiety, or other conditions this medication is used for.

Considering speaking with a therapist (talk therapy) can also be helpful in managing anxiety, mood changes, or other challenges that may arise when you stop treatment.

It is a good idea to inform your family and friends that you will be slowly discontinuing your treatment over several weeks or more. This way, they can understand that you might experience some side effects.

Maintaining a healthy diet, getting enough rest, and staying physically active to keep your body strong are important steps. If you notice your depression symptoms returning, be sure to reach out to your doctor promptly.

Possible Serious Cymbalta Effects

In rare cases, some people may encounter more severe side effects from Cymbalta, such as hallucinations and thoughts of self-harm.

How Long Does Cymbalta Withdrawal Last

The duration of Cymbalta withdrawal symptoms can vary, spanning from a few days to several weeks. The time it takes for these symptoms to subside depends on factors like how long you have been taking Cymbalta and your individual body response.

If you have been using Cymbalta for over six months, the withdrawal symptoms and the intensity of each symptom when you suddenly stop could be stronger and last longer.

Cymbalta Withdrawal Timeline

There is not a fixed schedule for Cymbalta withdrawal, but when you stop any antidepressant, it typically involves two phases: acute withdrawal and post-acute withdrawal syndrome (PAWS). Most of the time, withdrawal symptoms improve within 1 to 3 weeks.

Acute withdrawal involves physical symptoms like brain zaps, nausea, dizziness, headaches, tiredness, and difficulty sleeping. These symptoms usually begin within 1 to 3 days after discontinuing Cymbalta and may vary in duration and severity among individuals.

Post-acute withdrawal syndrome (PAWS) is a more extended phase that can last for six months or longer, influenced by factors like your body chemistry, initial dosage, and how long you took Cymbalta. PAWS symptoms can include feelings of unease and sadness, restlessness, mental confusion, trouble with cognitive tasks, and sleep disturbances.

When Does Cymbalta Withdrawal Peak

Cymbalta withdrawal can hit its worst point at different times for different people, but for most, the toughest symptoms tend to show up within 1 to 2 weeks after stopping the medication. Following this peak period, symptoms generally start to improve or go away, although they might linger for several weeks or even months in some instances. It is important to note that each person’s withdrawal experience is unique, and there is no fixed timetable for recovery.

How to Manage Cymbalta Withdrawal

Quitting Cymbalta can be quite challenging, especially if you stop suddenly. To minimize the risk of severe side effects or withdrawal symptoms, it’s important to have a well-thought-out plan.

Consult your doctor to determine the best approach for discontinuing Cymbalta. They will likely suggest a gradual reduction over a few weeks or months. Sometimes, they may recommend using over-the-counter medications like ibuprofen or acetaminophen to ease withdrawal discomfort.

How to Safely Stop Using Cymbalta

It is essential to never stop taking Cymbalta without discussing it with your doctor first. Together, you and your doctor can create a safe and effective plan to minimize the chances of withdrawal symptoms and make the process of coming off Cymbalta as smooth as possible.

Gradual Reduction: The recommended approach is to decrease your Cymbalta usage gradually. The specific timeline for this will depend on how long you have been taking Cymbalta and your dose. However, current best practices for tapering off antidepressants suggest reducing your use slowly over at least 4 weeks. This gradual reduction, known as “tapering down,” helps lessen the intensity of withdrawal symptoms as your body adjusts to its natural balance.

Self-Care: Taking care of yourself is another way to manage Cymbalta withdrawal symptoms. Practicing self-care, such as eating well, getting enough rest, and engaging in activities like yoga or meditation, can assist you in transitioning as you come off Cymbalta.

Consult with Your Doctor: Throughout this process, it’s essential to stay in touch with a mental health professional who has experience in managing medications like Cymbalta. They can offer valuable guidance on how to address potential challenges related to discontinuing the medication and provide strategies for dealing with any difficult emotions that may arise during this period.

How to Safely Reduce Your Cymbalta

If you want to stop using Cymbalta, it is essential to avoid quitting it suddenly, as it can be risky. Instead, reach out to your doctor or psychiatrist for guidance.

Under medical supervision, you can start a tapering process. This means you will gradually reduce your Cymbalta doses, which can lower the chances of experiencing severe withdrawal symptoms.

According to current recommendations, it is best to gradually taper off antidepressant medications over a period of at least 4 weeks. The specific tapering plan should consider factors like how long you have been taking the medication, your current dosage, and your individual medical history. This is why it is crucial to always taper off Cymbalta under the guidance of a doctor.

Sometimes, tapering off Cymbalta, or any antidepressant, might feel overwhelming. In such cases, your doctor might suggest temporarily going back on the medication and then tapering off at a slower pace. This approach can help reduce the intensity of side effects and make the process more manageable for you.


When you decide to quit using Cymbalta or any other antidepressant, you might go through withdrawal symptoms. That is why it is crucial never to stop or reduce Cymbalta on your own without a doctor’s guidance.

If you do face side effects while doing this, keep in mind that these symptoms are a short-term reaction to changes in your brain chemistry.

Getting support from healthcare professionals and loved ones, having over-the-counter medications ready to relieve symptoms, and openly discussing your feelings can all make the process smoother and more manageable.

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