All About Cymbalta

Cymbalta Ruined My Life

Cymbalta, which is also known generically as duloxetine, is a medication prescribed to treat a number of conditions, like depression, anxiety, fibromyalgia, and neuropathic pain. It belongs to a class of drugs known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs), which function by increasing the levels of serotonin and norepinephrine in the brain to help regulate mood and pain signals.

Cymbalta has been approved by the FDA for several conditions and is often prescribed to reduce pain, improve mood, and enhance overall functioning. Many patients start Cymbalta with high expectations, looking forward to relief from their symptoms and a better quality of life. In this article, we are going to talk more about “How Cymbalta Ruined My Life” and related concepts:

What is Cymbalta used for?

Cymbalta, also known by its generic name duloxetine, is used for several medical conditions:

  • Major Depressive Disorder: It is prescribed to adults for the treatment of depression, helping to improve mood and energy levels.
  •  Generalized Anxiety Disorder: It helps reduce anxiety and panic attacks in adults and children who are at least 7 years old.
  •  Nerve Pain: Cymbalta is used in adults to treat nerve pain caused by diabetes, known as diabetic neuropathy.
  •  Chronic Muscle or Joint Pain: It is also prescribed for chronic pain conditions like low back pain and osteoarthritis pain.
  •  Fibromyalgia: Adults and children at least 13 years old may be prescribed Cymbalta for this chronic pain disorder.

It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs) and works by helping to restore the balance of certain natural substances in the brain.

How does Cymbalta work?

Cymbalta, known by its generic name duloxetine, is a type of antidepressant called a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It works by increasing the levels of serotonin and norepinephrine, neurotransmitters that help regulate mood and may be unbalanced in people with depression. Cymbalta is used to treat major depressive disorder, general anxiety disorder, diabetic neuropathy, chronic muscle or joint pain, and fibromyalgia.

It is important to follow your doctor’s instructions when taking Cymbalta and be aware of potential side effects. If you have any concerns or experience any changes in mood or symptoms, it is crucial to consult with your healthcare provider.

Side effects of Cymbalta: Cymbalta Ruined My Life

However, not all experiences with Cymbalta are positive. Some people report severe side effects that significantly impact their lives. These can include chronic fatigue, dizziness, gastrointestinal issues, and even exacerbation of mental health problems. 

Withdrawal symptoms (That we will discuss later) are also a concern, with reports of “brain zaps,” nausea, insomnia, and irritability upon discontinuation. Here are some more side effects of Cymbalta:

  • Suicidal thoughts and behaviors (particularly in children, adolescents, and young adults)
  •  Liver damage, indicated by yellowing skin or eyes, upper right abdominal pain, dark urine, or clay-colored stools
  •  Serotonin syndrome, a potentially life-threatening condition with symptoms like agitation, hallucinations, rapid heart rate, and loss of coordination
  •  Severe skin reactions, such as rash, hives, blisters, or peeling skin
  •  Eye problems, like pain, changes in vision, or swelling around the eyes
  •  Difficulty urinating or changes in urine output
  •  Seizures

It is important to observe for these side effects and report any concerns to a doctor immediately.

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What is the biggest side effect of Cymbalta?

The most severe side effect of Cymbalta (duloxetine) is the risk of suicidal thoughts and behaviors, mainly in children, adolescents, and young adults. This is a serious concern that the FDA highlights, and it is important for patients and their caregivers to monitor for any changes in mood or behavior when starting the medication or adjusting the dose.

Other serious side effects include:

  • Liver damage
  •  Serotonin syndrome, a life-threatening condition
  •  Severe allergic reactions
  •  Eye problems
  •  Changes in blood pressure

These side effects are rare but can be serious and require immediate medical attention. Always consult with a doctor for medical advice and before making any changes to your medication 

How can I manage the side effects of tapering off Cymbalta?

Managing the side effects of tapering off Cymbalta (duloxetine) involves many strategies to ensure a change:

  • Follow a Tapering Plan: Stick to the tapering schedule prescribed by your doctor. This gradual reduction in dosage helps your body adjust and can reduce the severity of withdrawal symptoms.
  •  Medication for Symptoms: Over-the-counter medications may help alleviate symptoms like headache, nausea, and body aches. Always consult with your doctor before taking new medications to avoid interactions.
  •  Support System: Lean on friends, family, or support groups. Sharing your experiences and challenges can provide emotional support and practical advice during the tapering process.
  •  Integrative Remedies: Some people find relief in alternative therapies such as acupuncture, meditation, or yoga, which can help manage stress and withdrawal symptoms.
  •  Self-Care Practices: Engage in self-care activities that promote well-being, such as regular exercise, healthy eating, and sufficient sleep. These can help your body cope with the changes and improve your mood.
  •  Professional Guidance: If symptoms become too uncomfortable, contact your healthcare provider. They may adjust your tapering plan or suggest other interventions to help manage the side effects.

The main thing to manage side effects is a personalized approach under the guidance of a doctor.

How long does it take to get off of Cymbalta?

Discontinuing Cymbalta (duloxetine) should be done with proper caution and under medical supervision. The process typically involves a tapering strategy, where the dose is slowly reduced over time to minimize withdrawal symptoms. The duration of the taper can vary depending on individual factors, but it often lasts at least two weeks.

Most people experience withdrawal symptoms that are mild to moderate in intensity, and these can last for about one week for the majority of people. However, some may experience symptoms for longer, and in some cases, a more extended tapering period over several months may be necessary. It is essential to consult with a healthcare provider to develop a personalized plan for discontinuing Cymbalta safely.

Here are some key points about the discontinuation process:

  • Tapering Duration: At least two weeks, possibly longer depending on individual needs.
  •  Common Symptoms: May include dizziness, nausea, headache, irritability, and tingling skin sensations.
  •  Symptom Duration: For most, symptoms resolve within a week, but can last longer.
  •  Extended Tapering: Some individuals may require a slower taper over several months.

What are some common withdrawal symptoms of Cymbalta?

Common withdrawal symptoms of Cymbalta (duloxetine) can include:

  • Nausea
  •  Dizziness
  •  Headache
  •  Irritability
  •  Tingling skin sensations or “pins and needles”
  •  Vomiting
  •  Anxiety
  •  Nightmares or disturbing dreams
  •  Strange sensations like “brain zaps”
  •  Trouble sleeping

These symptoms mainly appear within two to four days of stopping the medication and can last for a few weeks.

Can I drink alcohol while taking Cymbalta?

It is generally not recommended to mix Cymbalta (duloxetine) with alcohol. Combining the Cymbalta and alcohol can lead to increased risk of liver damage, worsened side effects, and mood-related symptoms. 

If you are considering drinking alcohol while on Cymbalta, it is important to discuss this with your doctor, who can provide guidance based on your specific health needs and history.

Reviews of Cymbalta

There are a number of personal stories of people who feel their lives were negatively affected by Cymbalta. These accounts often describe a downward spiral where the medication, instead of providing relief, led to increased struggles including job loss, social isolation, and mental health crises.

For those facing difficulties with Cymbalta, the journey towards recovery can be challenging. It often involves working closely with healthcare professionals to safely discontinue the medication and find alternative treatments. Support from friends, family, and support groups can also play a crucial role in overcoming the hurdles posed by adverse drug reactions.

The experiences of those who have struggled with Cymbalta underscore the importance of informed decision-making when it comes to mental health treatment. It is important to have open discussions with healthcare providers about the potential risks and benefits of any medication.


While Cymbalta has helped many, it is clear that it can also have found negative effects on others. Sharing these experiences is vital for raising awareness and ensuring that patients make informed choices about their treatment options. If you or someone you know is struggling with the effects of Cymbalta, remember that you are not alone and that help is available.

People Also Ask

What is Cymbalta? 

Cymbalta is a medication known as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It is used to treat depression, anxiety, nerve pain, and other conditions.

How does Cymbalta work? 

Cymbalta works by increasing the levels of serotonin and norepinephrine in the brain, which can help improve mood and relieve pain.

Who can take Cymbalta? 

Cymbalta is prescribed for adults with depression, anxiety, diabetic neuropathy, chronic muscle or joint pain, and fibromyalgia. It is not approved for use by anyone younger than 7 years old.

Are there any side effects of taking Cymbalta? 

Yes, side effects can include nausea, dry mouth, sleepiness, fatigue, constipation, loss of appetite, and increased sweating. It is important to discuss any side effects with your doctor.

Can Cymbalta be taken with other medications? 

Cymbalta can interact with other medications, so it is important to tell your doctor about all the medicines you are taking. Avoid taking Cymbalta within 5 days before or 14 days after using an MAO inhibitor.

What should I do if I miss a dose of Cymbalta? 

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at one time.

How should Cymbalta be stored? 

Store Cymbalta at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.